https://dspace.iiti.ac.in:8080/jspui/handle/123456789/9536 2026-08-15T16:19:37Z https://dspace.iiti.ac.in:8080/jspui/handle/123456789/18850 Title: Structural basis of auto- proteolytic resistance of endoproteases and proteolytic susceptibility of mesophilic and thermophilic proteins [RESTRICTED THESIS-01 Year] Authors: Yadav, Beena Abstract: [Abstract is restricted for 01 Year, due to IPR related issue] 2026-06-22T00:00:00Z https://dspace.iiti.ac.in:8080/jspui/handle/123456789/18768 Title: From emissions to innovations: integrated algal biorefinery for CO2 sequestration and metabolomics-guided profiling Authors: Sangtani, Rimjhim Abstract: The rapid increase in the concentration of the most significant greenhouse gas, CO2, predominantly driven by anthropogenic activities, has heightened the worldwide need for sustainable, nature-based carbon sequestration strategies. Over the past few years, microalgae have been scrutinized by the research community and have emerged as promising candidates for CO2 mitigation, as well as bioproduct generation. This is due to their remarkable photosynthetic efficiency, rapid proliferation, and potential to convert CO2 and energy into algal biomass and high-value metabolites. However, amidst the increasing emphasis on CO2 mitigation strategies via microalgae, research gaps exist that hinder the adaptation of a sustainable circular biorefinery approach that incorporates CO2 mitigation, microalgae-assisted wastewater treatment, and bioproduct formation. To begin with, limited knowledge of the physiological and metabolic response of the indigenously isolated microalgae to nutrient availability, coupled with elevated CO2. Furthermore, studies focused on systematically optimizing CO2 sparging conditions, such as aeration rate, sparging concentration, and sparging duration to improve the carbon fixation efficiency of microalgae while minimizing energy requirements, are very scarce. Subsequently, the application of untargeted metabolomics to investigate the metabolic reprogramming of microalgae under CO2 supplementation and its translation into the valorization of organic waste to produce essential bioproducts remains underexplored. The present thesis focuses on addressing these significant bottlenecks by evaluating the CO2 capture and utilization dynamics, metabolic signature, and bioproduct generation ability of an indigenously isolated microalga, Scenedesmus sp., from the Indore region, India. 2026-04-24T00:00:00Z https://dspace.iiti.ac.in:8080/jspui/handle/123456789/18767 Title: Therapeutic targeting of TIRAP: translating molecular insights into anti-inflammatory strategies against sepsis Authors: Atre, Rajat Abstract: Sepsis owing to its complex nature still remains a difficult challenge in the medical community. The pathophysiology itself is what makes it so challenging to manage. The uncontrolled pathogenic load and the resulting dysregulated host immune response are the key reasons for its rapid widespread. The traditional approaches consist of the usage of monoclonal antibody, antibiotics, supportive care, and fluid resuscitation. Despite all these efforts sepsis still remains at the top for claiming millions of lives. One area that has not been much explored is the host targeted strategy. This paved the way for the current research work. We, investigate the role of TLR4 dependent TIRAP mediated pro-inflammatory immune signaling. TIRAP holding the top most position in the signaling cascade makes it an attractive and suitable target to explore. Not only has this but TIRAP’s ability to interact with various proteins also made it an approachable target. TIRAP is known to get phosphorylated and activated by the activity of two kinases. They comprise Protein Kinase C δ (PKCδ) and Bruton’s Tyrosine Kinase (BTK). An in depth analysis of TIRAP’s such interactions and its structural biology helped us to form a basic understanding of its working pattern. 2026-04-24T00:00:00Z https://dspace.iiti.ac.in:8080/jspui/handle/123456789/18466 Title: Identification of microalgal and cyanobacterial metabolites for type 2 diabetes therapeutics [RESTRICTED THESIS-06 Months] Authors: Anshul Abstract: [Abstract is restricted for 06 months, due to IPR related issue] 2026-05-21T00:00:00Z