Engineering of a solution phase efficient pathway for the development of nucleobase containing chimeric compounds

Abstract

Nucleopeptides are an important class of molecules having diverse applications in therapeutics, diagnostics and biomaterials development. The nucleopeptides have significant importance due to their ability to target complementary DNA and RNA strands. In addition, these compounds have interesting self-assembly properties and are used as self replicating materials in prebiotic chemistry and constituents of drug delivery systems. Therefore, we have focused on synthesising purine functionalised amino acids derivatives. All the intermediates are purified using column chromatography and characterised by mass spectrometry and NMR spectroscopy.