Design, synthesis and biological evaluation of heterocycles for tuberculosis

Abstract

Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis. Currently, finding a cure to such a deadly disease is a matter of concern. Both multi-drug resistant TB and extremely drug-resistant TB are threats to success in the anti-TB programs. A rapid increase in cases of the resistance strains introduced an urgent requirement to develop new chemical compounds with improved efficacy. Azaindole is a promising core for anti-TB agents. Azaindoles have become an integral core moiety in the critical drug candidates. The present thesis work describes the synthesis and characterization of pyrrolopyridine-isatin hybrids. These hybrids serve as competitive inhibitors of polyketide synthetase 13 (Pks13), inhibiting mycolic acid synthesis. Moreover, these molecules can be further examined in the treatment of tuberculosis.