Photoluminescence properties of nano composite materials

Abstract

Luminescent biocompatible gold nanoclusters have tremendous importance in various fields. Here, we have successfully synthesized the GSH capped gold nanoclusters by taking the auric chloride and GSH. After this, we have utilized this negatively charged gold nanocluster to form the self-assembled structures in the presence of polycation. The creation of evenly distributed, persistent, and spherical inherently luminous Au NC droplets is extended by self-assembly between gold nanoclusters and polycation, according to our findings. To know the effect of pH and salt, the turbidity profile of the binary mixture has been observed at different pH and at different concentrations of NaCl. Next, we have loaded an anti-cancer drug doxorubicin inside Au NC droplets. The value of equilibrium partition coefficient in case of DOX was found to be 61.5 ± 2.5 which is calculated via Uv-vis spectroscopy. The high value of K indicates sequestration which is caused by hydrophobic and electrostatic interactions. We have explained preferential sequestration and release profile of anticancer drug DOX in different condition inside these Au NC droplets. To make the droplets more robust we have investigated the release profile after making a lipid shell so that slow drug release happens and disassembly of droplet will be slower and we get a preferential result by using DPPC liposome. These present observations make them a suitable candidate towards diverse applications namely nano carrier for drug delivery in various tumor cells.