Hypervalent iodine reagent mediated halocyclization of N-Arylpropynamides

Abstract

Researchers are currently interested in the synthesis of Heterocyclic spiro compound, because of this biological activity. The main aim of thesis is to develop hypervalent iodine reagent mediated oxidative hallocyclization of 4-para unsubstituted n-aryl propynamides. Our method is more effective than other method because all product reaction is setup on room temperature without using Heat or light. This method is applicable both substituted and unsubstituted n-aryl propynamides. All the synthesized molecules are characterized by using different analytical technique such as 1H, 13C NMR and Sc-XRD.