Magnetic-PLGA nanohybrids as theranostics against cancer

Abstract

Cancer has been a deadly disease so far with millions of deaths annually. There are enormous trails going on towards the prevention and cure of this disease, developing various kinds of therapies. Due to adverse side effects in all the current therapies of cancer, specifically with synthetic chemotherapeutic drugs, the current research is more towards phytochemicals due to their antioxidant, anti-inflammatory and anti-cancer properties. In the recent studies various phytochemicals have shown considerable cytotoxicity towards different kinds of cancer but they also face some problems with their poor solubility, specificity and bioavailability. In this case nanotechnology comes into effect which is proven for the various modification of the nanoparticles leading to more improved drug delivery. PLGA and MNP have been used since long for drug delivery leading to more sustained and specific drug bioavailability protecting from degradation to its target site. This thesis aims to investigate the use of piperine and camptothecin-loaded PLGA and MNP-based drug delivery systems for cancer therapy, with a focus on their mechanisms of action and potential clinical applications. The current state of cancer therapy, the properties and applications of the compounds and delivery systems, and their potential for cancer treatment will be discussed.