Drug Delivery Systems to the Peritoneum: Current Status and Future Perspectives

Abstract

Intraperitoneal drug delivery systems provide a regional therapy model for the peritoneal and also relatively increase the half-life and concentration of the desired drug molecule in the peritoneum cavity. Current studies and research suggest IP delivery is a promising technique for drug delivery against peritoneal drug delivery as compared to conventional systemic administration. However, the peritoneal drug delivery system faces many challenges like premature clearance of low molecular weight molecules, lack of specific targeting, and poor penetration ability of cells. Recent studies suggest the use of different nanoparticles may improve drug targeting. These drug delivery systems have been explored in various animal models. This chapter aimed to provide an overview of various types of drug delivery systems and provide preclinical data about the animal studies used in peritoneal studies. Future studies in the chapter mainly focus on improving the clinical relevance of the experiments, standardizing the experimental study setup, and improving their methodological quality and reporting. © Springer Nature Switzerland AG 2023.