An expedient access to aminoquinazolines and quinazolinones via N-atom insertion reaction using copper nano particles decorated on magnetic carbon spheres

Abstract

The traditional catalytic materials for catalysis typically exhibit a lack of recyclability after the fresh cycle. Consequently, it is imperative to create materials that are more effective in recycling and reuse. Hence, this work presents a new sustainable method for producing copper nanoparticles decorated on magnetic carbon spheres (Cu@MCS) using reduction method for the first time. The authentication of the successful synthesis of Cu@MCS is confirmed using several analytical and spectroscopic characterization techniques. Additionally, an investigation was conducted to assess the catalytic efficiency of Cu@MCS for the synthesis of pharmaceutically significant 4-aminoquinazolines and quinazolinone derivatives. This study aimed to provide a cost-effective, sustainable, and base-free approach, eliminating the need for external ligands or additives under green solvent. The molecular complexation of the produced N-heterocycles and the effective synthesis of targets on a large scale have been achieved. In addition, the catalyst's recyclability and reuse by using external magnetic field, control studies, and the mechanistic elucidation of the processes were thoroughly examined. © 2024 Elsevier Ltd