Visible light-induced photo-redox catalysis and dual catalysis for C–H functionalization of 2-phenyl-4H-pyrido[1,2-a] pyrimidin-4-one and 2-aryl heterocycles

Abstract

This thesis aims to investigate the potential of modern advancements in carbon-carbon (C–C) bond formation, with a specific emphasis on C–H activation and functionalization facilitated by visible light-mediated photo-redox catalysis and transition metal catalysis. These innovative strategies enable the construction of C–C bonds under mild conditions, typically at room temperature, offering a greener and more sustainable approach to synthetic transformations. In Chapter 1, we introduced the literature study of coupling reactions, particularly for C-C bond formation facilitated by transition metal catalysts. This discussion was extended to include visible-light photoinduced pathways for C-H functionalization, highlighting their growing significance in modern organic synthesis. Furthermore, advanced methodologies that integrate photocatalysis with transition metal catalysis to achieve efficient C-C bond formation, emphasizing their innovative potential have been discussed. Finally, we briefly discussed the importance of 2-phenyl-4H-pyrido[1,2-a]pyrimidin-4-one and reviewed previous reports on the synthesis and functionalization of 2-phenyl-4H-pyrido[1,2-a]pyrimidin-4-one, providing a foundation for further exploration in this area. Current thesis work focuses on the regio-selective C–H activation and subsequent functionalization, such as arylation, acylation, alkylation, and alkenylation of 2-Phenyl-4H-pyrido[1,2-a]pyrimidin-4-one and related heterocycles under visible light photo-redox catalytic conditions or through the synergistic merging of photo-redox with transition metal catalysis.