Guanosine 5’-monophosphate as a small biomolecule hydrogelator to form supramolecular hydrogels with metal-oxo nanoclusters, metal complex, and small organic molecule: synthesis, characterization, and applications

Abstract

Supramolecular chemistry forms the foundation of self-assembly, where the structural motifs of individual molecules encode instructions for assembling into larger entities. Molecular self-assembly is the spontaneous organization of molecules into ordered hierarchical structures directed by noncovalent interactions such as hydrogen bonding, π-π stacking, electrostatic interactions, Van-der-Waal forces, and hydrophobic interactions etc. Self-assembly is a widespread phenomenon in nature, where a high degree of sophistication is achieved through the ensemble of the various components into a well-defined pattern, such as in protein folding, lipid bilayer formation, and hybridization of the DNA double helix etc.1,2 Gels are distinguished soft colloidal states of matter embraced with viscoelastic properties which comprised of a continuous 3D cross-linked network with entrapped solvent inside.