Trials towards visible light catalysed dearomative spiro-amidation

Abstract

As we are trying to synthesize Spiro-Amide from the Phenolic ester using RFTA in an efficient and Sustainable pathway by generating in situ tribromide from ammonium bromide, which was very challenging due to the amide generation is not possible under visible light conditions. We synthesize Phenolic amid as a starting material and form a variety of Spiro-Amides using RFTA and iodide source as tetra-butyl ammonium Iodide (TBAI) yield of 27 %.