Nanomanufacturing in the Biomedical Field

Abstract

Nanomanufacturing is revolutionizing the biomedical field by enabling the precise fabrication of nanoscale materials and devices that address complex medical challenges. This approach harnesses the unique properties of nanomaterials to enhance drug delivery, diagnostics, tissue engineering, and medical implants. Advanced nanofabrication techniques allow for the creation of targeted drug delivery systems that improve therapeutic outcomes while minimizing side effects. In diagnostics, nanosensors enable early disease detection with unprecedented sensitivity, and nanomaterials enhance imaging accuracy. Nanostructured scaffolds in tissue engineering promote faster healing and organ regeneration, while nanotechnology-enhanced implants and prosthetics improve biocompatibility and functionality. In addition, nanomanufacturing in cancer treatment involves the design and fabrication of nanoscale materials to enhance both the diagnosis and therapy of cancer. This approach enables targeted drug delivery, allowing anticancer agents to be released directly at the tumor site, reducing damage to healthy tissues and minimizing side effects. Additionally, nanoparticles (NPs) improve imaging techniques, making cancer detection more accurate. Multifunctional NPs, known as theranostics, combine diagnostic and therapeutic functions, enabling personalized treatment. Nanotechnology also offers innovative therapies, such as photothermal and photodynamic treatments, that selectively destroy cancer cells. Overall, nanomanufacturing holds great promise for more precise, effective, and personalized cancer care. One of the many difficulties facing biomedical nanomanufacturing is the need to scale up production while preserving accuracy, repeatability, and quality control. Another major challenge is ensuring that nanomaterials are safe and biocompatible. Unpredictable interactions between NPs and biological systems raise questions about toxicity and long-term consequences. Nanomedicine regulatory approval procedures are likewise difficult and drawn out, requiring a lot of testing. The development of more dependable and economical production methods enhanced real-time monitoring of nanoparticle behavior in the body, and the creation of uniform safety and efficacy protocols are the main goals of future directions in nanomanufacturing. Interdisciplinary cooperation will be crucial as the field develops to get past these obstacles and realize the full potential of nanomedicine in healthcare. This chapter explores the principles, techniques, and applications of nanomanufacturing in biomedicine, highlighting recent advancements and addressing challenges related to scalability, regulation, and ethics. By providing a comprehensive overview, this chapter underscores the critical role of nanomanufacturing in advancing personalized medicine and shaping the future of healthcare. © 2025 Elsevier B.V., All rights reserved.