Synthesis and characterization of 2-iminocoumarins and cyclic n-sulfonyl ketimines

Abstract

There is a growing interest in creating synthetic processes that are friendly to the environment. These processes are for making important heterocycles, like cyclic N-sulfonyl ketimines, using C-C functionalization. This is especially true when these methods follow the principles of green chemistry. The main goal is to improve how efficiently these reactions work while also considering financial and environmental issues. Nitrogen-containing heterocycles are commonly utilized as fundamental components in the field of synthesis and serve as essential structural units in the drug discovery process. Cyclic N-sulfonyl ketimines have served important roles in the synthesis of various products possessing heteroatomic functional groups.[1-2] cyclic N-sulfonyl ketimines represent a very suitable platform for the preparation of this interesting class of heterocyclic compounds for their application in the pharmaceutical industry and drug discovery.[3] N-sulfonyl enamine as a suitable donor would possibly make a C-C bond. The Cyclic N-sulfonyl ketimines as nucleophilic partners were efficiently coupled with a diverse range of nucleophilic acceptors to construct interesting classes of a wide array of heterocyclic molecules. Cyclic N-sulfonyl ketimines as fundamental building blocks in organic synthesis are widely implicated in medicinal chemistry, and the compounds containing N-sulfonyl imine moieties are normally biologically active molecules. Cyclic N-sulfonyl ketimines are important for creating various products that contain functional groups with heteroatoms. The proton of alcohols as the sole hydrogen source in diborane-mediated nickel-catalysed asymmetric transfer hydrogenation of cyclic N-sulfonyl ketimines has been developed, providing the chiral cyclic N-sulfonyl in excellent enantioselectivities.