Palladium-Catalyzed Photoinduced Regioselective C8 Arylation of 1-(Pyridin-2-yl)quinolin-4(1H)-Ones with Aryl Diazonium Salts

Please use this identifier to cite or link to this item: https://dspace.iiti.ac.in/handle/123456789/17311

Title:	Palladium-Catalyzed Photoinduced Regioselective C8 Arylation of 1-(Pyridin-2-yl)quinolin-4(1H)-Ones with Aryl Diazonium Salts
Authors:	Surve, Shivaji V. Bhawale, Rajesh T. Biswas, Biswajit Kshirsagar, Umesh A.
Keywords:	aryl diazonium salt;arylation;dual catalysis;heterocycles;quinolinone
Issue Date:	2025
Publisher:	John Wiley and Sons Inc
Citation:	Surve, Shivaji V., Bhawale, R. T., Biswas, B., & Kshirsagar, U. A. (2025). Palladium-Catalyzed Photoinduced Regioselective C8 Arylation of 1-(Pyridin-2-yl)quinolin-4(1H)-Ones with Aryl Diazonium Salts. European Journal of Organic Chemistry. https://doi.org/10.1002/ejoc.202500961
Abstract:	A visible-light-mediated regioselective C8 arylation of quinolinones has been developed by merging transition-metal catalysis with photoredox catalysis. This approach offers broad substrate scope and mild reaction conditions, affording the desired products in up to 85% yield. Furthermore, to investigate the reaction mechanism, several control experiments were performed, including fluorescence quenching studies, quantum yield measurements, light-on/off experiments, kinetic isotope effect (KIE) analysis, and H/D labeling experiments. This strategy exhibits excellent scalability and also enables subsequent C2 alkenylation. © 2025 Wiley-VCH GmbH.
URI:	https://dx.doi.org/10.1002/ejoc.202500961 https://dspace.iiti.ac.in:8080/jspui/handle/123456789/17311
ISSN:	1434-193X 1099-0690
Type of Material:	Journal Article
Appears in Collections:	Department of Chemistry

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