Synthesis, characterization and applications of trinuclear complexes with Schiff base ligands

Abstract

The present work of the thesis sums up the results of the findings on the synthesis, structural analyses, and spectral properties of some Schiff base complexes. Herein, three new trinuclear metal complexes from Schiff base ligand H2L (H2L = 2,2'-((1E,1'E) -(propane-1,3-diylbis(azaneylylidene))bis(methaneylylidene))diphenol) have been synthesized. Among them, one is a zinc Schiff base complex (1), and the remaining two are nickel Schiff base complexes (2 and 3) with 5-substituted-1-H-tetrazole as a bridging ligand. All the complexes are characterized through ESI-MS, Elemental analyses and IR spectroscopy. Single crystal X-ray diffraction analyses have been done for all the three complexes 1, 2 and 3. Structural study reveals that the zinc (II) complex (1) is trinuclear and crystallizes in monoclinic system with space group P 21/c and both complexes 2 and 3 ( nickel complexes) are trinuclear with triclinic crystal system and space group P- 1. Complex 1 has been found to be catalytically active in mimicking the functionalities of the metalloenzyme, phenoxazinone synthase (PHS). Interactions of complexes 2 and 3 with proteins (BSA and HSA) have been also studied to establish their potent role as metal-drug system.