Photoluminescence from self-assembled nanocomposites

Abstract

Various neurogenerative disorders such as Parkinson's disease, Alzheimer and other amyloidosis have not found a cure yet and thus need to be studied. These neurogenerative disorders involve protein misfolding, thus resulting in the formation of amyloid. Our main objective is to study the photoluminescence of protein and the fabrication of protein assemblies. Photoluminescence involves spontaneous emission of radiation from electronically or vibrationally excited species upon upon absorption of radiation. Fluorescence is photoluminescence. We have also tried to explore the physiochemical properties of these assemblies. In this thesis, we have attempted to inspect human serum albumin's time and temperature-dependent fluorescence, one of the most abundant protein in the human body, with a polyethylene glycol(PEG crowder).