P-gp pathophysiology: Post-translational modification and affecting signaling cascades

Abstract

The PTMs (Post-translational modifications) play a pivotal role in regulating various biological functions, e.g., protein stability and its localization, and regulation of different enzymatic activity. Post-translational changes have been shown to modulate a wide range of molecular pathways along with the functional expression of the drug transporter. These modifications usually occur by adding residues of solvent-accessible amino acids to functional groups (phosphorylation), small proteins (ubiquitination), sugar chains (glycosylation) or lipids (palmitoylation). This chapter highlights the role of drug transporter, its function and importance of post-translational modifications to understand their roles in drug transporter regulation and its process. © 2021 Nova Science Publishers, Inc. All rights reserved.