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Please use this identifier to cite or link to this item: https://dspace.iiti.ac.in/handle/123456789/3833
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dc.contributor.authorJakhmola, Shwetaen_US
dc.contributor.authorJain, Khushbooen_US
dc.contributor.authorJha, Hem Chandraen_US
dc.date.accessioned2022-03-17T01:00:00Z-
dc.date.accessioned2022-03-17T15:30:46Z-
dc.date.available2022-03-17T01:00:00Z-
dc.date.available2022-03-17T15:30:46Z-
dc.date.issued2021-
dc.identifier.citationJakhmola, S., Upadhyay, A., Jain, K., Mishra, A., & Jha, H. C. (2021). Herpesviruses and the hidden links to multiple sclerosis neuropathology. Journal of Neuroimmunology, 358 doi:10.1016/j.jneuroim.2021.577636en_US
dc.identifier.issn0165-5728-
dc.identifier.otherEID(2-s2.0-85108448751)-
dc.identifier.urihttps://doi.org/10.1016/j.jneuroim.2021.577636-
dc.identifier.urihttps://dspace.iiti.ac.in/handle/123456789/3833-
dc.description.abstractHerpesviruses like Epstein-Barr virus, human herpesvirus (HHV)-6, HHV-1, VZV, and human endogenous retroviruses, have an age-old clinical association with multiple sclerosis (MS). MS is an autoimmune disease of the nervous system wherein the myelin sheath deteriorates. The most popular mode of virus mediated immune system manipulation is molecular mimicry. Numerous herpesvirus antigens are similar to myelin proteins. Other mechanisms described here include the activity of cytokines and autoantibodies produced by the autoreactive T and B cells, respectively, viral déjà vu, epitope spreading, CD46 receptor engagement, impaired remyelination etc. Overall, this review addresses the host-parasite association of viruses with MS. © 2021 Elsevier B.V.en_US
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.sourceJournal of Neuroimmunologyen_US
dc.subjectalpha crystallinen_US
dc.subjectautoantibodyen_US
dc.subjectbeta crystallinen_US
dc.subjectcytokineen_US
dc.subjectepitopeen_US
dc.subjectmembrane cofactor proteinen_US
dc.subjectmyelin proteinen_US
dc.subjectvirus antigenen_US
dc.subjectB lymphocyteen_US
dc.subjectCD4+ T lymphocyteen_US
dc.subjectcell immortalizationen_US
dc.subjectCytomegalovirusen_US
dc.subjectdisease associationen_US
dc.subjectEpstein Barr virusen_US
dc.subjectEpstein Barr virus infectionen_US
dc.subjectHerpesviridaeen_US
dc.subjecthost parasite interactionen_US
dc.subjecthumanen_US
dc.subjectHuman alphaherpesvirus 1en_US
dc.subjectHuman endogenous retrovirusen_US
dc.subjectHuman herpesvirus 6en_US
dc.subjectlymphocyte activationen_US
dc.subjectmolecular mimicryen_US
dc.subjectmultiple sclerosisen_US
dc.subjectnonhumanen_US
dc.subjectremyelinizationen_US
dc.subjectReviewen_US
dc.subjectsignal transductionen_US
dc.subjectVaricella zoster virusen_US
dc.titleHerpesviruses and the hidden links to Multiple Sclerosis neuropathologyen_US
dc.typeReviewen_US
Appears in Collections:Department of Biosciences and Biomedical Engineering

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