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  3. Department of Biosciences and Biomedical Engineering
Please use this identifier to cite or link to this item: https://dspace.iiti.ac.in/handle/123456789/3849
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dc.contributor.authorBishnoi, Sumanen_US
dc.contributor.authorKumari, Anshuen_US
dc.contributor.authorRehman, Sheebaen_US
dc.contributor.authorNayak, Debasisen_US
dc.contributor.authorGupta, Sharaden_US
dc.date.accessioned2022-03-17T01:00:00Z-
dc.date.accessioned2022-03-17T15:30:50Z-
dc.date.available2022-03-17T01:00:00Z-
dc.date.available2022-03-17T15:30:50Z-
dc.date.issued2021-
dc.identifier.citationBishnoi, S., Kumari, A., Rehman, S., Minz, A., Senapati, S., Nayak, D., & Gupta, S. (2021). Fusogenic viral protein-based near-infrared active nanocarriers for biomedical imaging. ACS Biomaterials Science and Engineering, 7(7), 3351-3360. doi:10.1021/acsbiomaterials.1c00267en_US
dc.identifier.issn2373-9878-
dc.identifier.otherEID(2-s2.0-85109042307)-
dc.identifier.urihttps://doi.org/10.1021/acsbiomaterials.1c00267-
dc.identifier.urihttps://dspace.iiti.ac.in/handle/123456789/3849-
dc.description.abstractAn effective drug delivery system (DDS) relies on an efficient cellular uptake and faster intracellular delivery of theranostic agents, bypassing the endosomal mediated degradation of the payload. The use of viral nanoparticles (VNPs) permits such advancement, as the viruses are naturally evolved to infiltrate the host cells to deliver their genetic material. As a proof of concept, we bioengineered the vesicular stomatitis virus glycoprotein (VSV-G)-based near-infrared (NIR) active viral nanoconstructs (NAVNs) encapsulating indocyanine green dye (ICG) for NIR bioimaging. NAVNs are spherical in size and have the intrinsic cellular-fusogenic properties of VSV-G. Further, the NIR imaging displaying higher fluorescence intensity in NAVNs treated cells suggests enhanced cellular uptake and delivery of ICG by NAVNs compared to the free form of ICG. The overall study highlights the effectiveness of VSV-G-based VNPs as an efficient delivery system for NIR fluorescence imaging. © 2021 American Chemical Society.en_US
dc.language.isoenen_US
dc.publisherAmerican Chemical Societyen_US
dc.sourceACS Biomaterials Science and Engineeringen_US
dc.subjectControlled drug deliveryen_US
dc.subjectFluorescence imagingen_US
dc.subjectMedical imagingen_US
dc.subjectTargeted drug deliveryen_US
dc.subjectTheranosticsen_US
dc.subjectVirusesen_US
dc.subjectBiomedical imagingen_US
dc.subjectDrug delivery systemen_US
dc.subjectFluorescence intensitiesen_US
dc.subjectIndocyanine green dyeen_US
dc.subjectIntracellular deliveryen_US
dc.subjectNir fluorescence imagingen_US
dc.subjectVesicular stomatitis virusen_US
dc.subjectViral nanoparticlesen_US
dc.subjectInfrared devicesen_US
dc.subjectbeta actinen_US
dc.subjectbeta interferonen_US
dc.subjectgamma interferonen_US
dc.subjectindocyanine greenen_US
dc.subjectinterferon regulatory factor 3en_US
dc.subjectnanocarrieren_US
dc.subjectvirus glycoproteinen_US
dc.subjectvirus like nanoparticleen_US
dc.subjectindocyanine greenen_US
dc.subjectnanoparticleen_US
dc.subjectviral proteinen_US
dc.subjectabsorption spectroscopyen_US
dc.subjectanimal experimenten_US
dc.subjectanimal tissueen_US
dc.subjectArticleen_US
dc.subjectbiocompatibilityen_US
dc.subjectcell viabilityen_US
dc.subjectcomparative studyen_US
dc.subjectcontrolled studyen_US
dc.subjectcytotoxicityen_US
dc.subjectdiagnostic imagingen_US
dc.subjectdispersityen_US
dc.subjectdrug delivery systemen_US
dc.subjectdrug releaseen_US
dc.subjectdrug stabilityen_US
dc.subjectembryoen_US
dc.subjectendosomeen_US
dc.subjectexpression vectoren_US
dc.subjectfemaleen_US
dc.subjectfluorescence imagingen_US
dc.subjectfluorescence intensityen_US
dc.subjectgene expressionen_US
dc.subjectgenetic transfectionen_US
dc.subjectHEK293T cell lineen_US
dc.subjectHeLa cell lineen_US
dc.subjecthistopathologyen_US
dc.subjecthumanen_US
dc.subjecthuman cellen_US
dc.subjecthydrodynamicsen_US
dc.subjectimmune response geneen_US
dc.subjectin vitro studyen_US
dc.subjectinnate immunityen_US
dc.subjectinternalization (cell)en_US
dc.subjectlight exposureen_US
dc.subjectmolecular imagingen_US
dc.subjectmouseen_US
dc.subjectnanoencapsulationen_US
dc.subjectnanofabricationen_US
dc.subjectnanopharmaceuticsen_US
dc.subjectnear infrared spectroscopyen_US
dc.subjectNIH 3T3 cell lineen_US
dc.subjectnonhumanen_US
dc.subjectparticle sizeen_US
dc.subjectphoton correlation spectroscopyen_US
dc.subjectplasmiden_US
dc.subjectstatic electricityen_US
dc.subjecttransmission electron microscopyen_US
dc.subjectultraviolet visible spectrophotometryen_US
dc.subjectVesiculovirusen_US
dc.subjectvirus plaqueen_US
dc.subjectWestern blottingen_US
dc.subjectzeta potentialen_US
dc.subjectdrug delivery systemen_US
dc.subjectfluorescenceen_US
dc.subjectDrug Delivery Systemsen_US
dc.subjectFluorescenceen_US
dc.subjectIndocyanine Greenen_US
dc.subjectNanoparticlesen_US
dc.subjectViral Proteinsen_US
dc.titleFusogenic viral protein-based near-infrared active nanocarriers for biomedical imagingen_US
dc.typeJournal Articleen_US
Appears in Collections:Department of Biosciences and Biomedical Engineering

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