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Please use this identifier to cite or link to this item: https://dspace.iiti.ac.in/handle/123456789/4040
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dc.contributor.authorChelvam, Venkateshen_US
dc.date.accessioned2022-03-17T01:00:00Z-
dc.date.accessioned2022-03-17T15:31:27Z-
dc.date.available2022-03-17T01:00:00Z-
dc.date.available2022-03-17T15:31:27Z-
dc.date.issued2017-
dc.identifier.citationPoh, S., Chelvam, V., Kelderhouse, L. E., Ayala-López, W., Vaitilingam, B., Putt, K. S., & Low, P. S. (2017). Folate-conjugated liposomes target and deliver therapeutics to immune cells in a rat model of rheumatoid arthritis. Nanomedicine, 12(20), 2441-2451. doi:10.2217/nnm-2017-0166en_US
dc.identifier.issn1743-5889-
dc.identifier.otherEID(2-s2.0-85030640037)-
dc.identifier.urihttps://doi.org/10.2217/nnm-2017-0166-
dc.identifier.urihttps://dspace.iiti.ac.in/handle/123456789/4040-
dc.description.abstractAim: We endeavored to create a folate-targeted liposome (Fol-liposome) that could selectively target areas of inflammation. Materials & methods: Fol-liposomes were prepared with encapsulated DiD fluorophore or betamethasone (BM) to image and treat an adjuvant-induced rat model of rheumatoid arthritis. Results: Fol-liposomes selectively accumulated in arthritic rat paws to a greater extent than nontargeted liposomes. When these Fol-liposomes were used to encapsulate BM and administered to arthritic rats, animals exhibited less paw swelling, lower arthritis scores, a reduction in bone erosion, less splenomegaly and better maintenance of body weight when compared with nontreated or nontargeted BM-containing liposome groups. Conclusion: Fol-liposomes can selectively deliver imaging and therapeutic agents to sites of inflammation in a rat model of rheumatoid arthritis. © 2017 2017 Future Medicine Ltd.en_US
dc.language.isoenen_US
dc.publisherFuture Medicine Ltd.en_US
dc.sourceNanomedicineen_US
dc.subjectbetamethasoneen_US
dc.subjectfolic aciden_US
dc.subjectliposomeen_US
dc.subjectfluorescent dyeen_US
dc.subjectfolate transporteren_US
dc.subjectfolic aciden_US
dc.subjectimmunological adjuvanten_US
dc.subjectliposomeen_US
dc.subjectanimal cellen_US
dc.subjectanimal experimenten_US
dc.subjectanimal modelen_US
dc.subjectArticleen_US
dc.subjectbioaccumulationen_US
dc.subjectbone erosionen_US
dc.subjectcell isolationen_US
dc.subjectcontrolled studyen_US
dc.subjectdrug coatingen_US
dc.subjectdrug delivery systemen_US
dc.subjectdrug dosage form comparisonen_US
dc.subjectdrug efficacyen_US
dc.subjectdrug safetyen_US
dc.subjectdrug targetingen_US
dc.subjectimmunocompetent cellen_US
dc.subjectin vivo studyen_US
dc.subjectmacrophageen_US
dc.subjectnonhumanen_US
dc.subjectpriority journalen_US
dc.subjectraten_US
dc.subjectrheumatoid arthritisen_US
dc.subjectsplenomegalyen_US
dc.subjectanimalen_US
dc.subjectchemistryen_US
dc.subjectdrug releaseen_US
dc.subjectexperimental arthritisen_US
dc.subjectfemaleen_US
dc.subjectfluorescence imagingen_US
dc.subjectimmunologyen_US
dc.subjectinflammationen_US
dc.subjectLewis raten_US
dc.subjectmetabolismen_US
dc.subjectmolecularly targeted therapyen_US
dc.subjectparticle sizeen_US
dc.subjectpathologyen_US
dc.subjectproceduresen_US
dc.subjectrheumatoid arthritisen_US
dc.subjectsurface propertyen_US
dc.subjectAdjuvants, Immunologicen_US
dc.subjectAnimalsen_US
dc.subjectArthritis, Experimentalen_US
dc.subjectArthritis, Rheumatoiden_US
dc.subjectDrug Liberationen_US
dc.subjectFemaleen_US
dc.subjectFluorescent Dyesen_US
dc.subjectFolic Aciden_US
dc.subjectFolic Acid Transportersen_US
dc.subjectInflammationen_US
dc.subjectLiposomesen_US
dc.subjectMacrophagesen_US
dc.subjectMolecular Targeted Therapyen_US
dc.subjectOptical Imagingen_US
dc.subjectParticle Sizeen_US
dc.subjectRatsen_US
dc.subjectRats, Inbred Lewen_US
dc.subjectSurface Propertiesen_US
dc.titleFolate-conjugated liposomes target and deliver therapeutics to immune cells in a rat model of rheumatoid arthritisen_US
dc.typeJournal Articleen_US
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