Synthesis, characterization and application of transition metal complexes in bio-inorganic chemistry

Abstract

Metal complexes of Schiff base ligands possess suitable biometric properties that can mimic the active sites and hence have wide applications in treatment of various ailments, biochemical reactions and also as biological regulators. The present work of this thesis stems from our interest to explore the structural and functional properties of Schiff base complexes. Henceforth four new monomeric complexes from Schiff base ligand [(E)-1-(((2-hydroxypropyl)imino)methyl)naphthalen-2-ol] (H2L) have been synthesized. Two of which are of Cu (complexes 1 and 2) and the remaining two are of Ni and Mn (complexes 3 and 4) respectively. All the complexes are characterized by ESI-MS, IR spectroscopy and elemental analyses. X-ray crystallography studies done for complexes 1 and 2 revealed that complex 1 is monoclinic in nature with square pyramidal geometry whereas the complex 2 is square planar triclinic crystal system. All the complexes were screened for catechol oxidation using 3,5-ditertiarybutyl catechol (3,5-DTBC) as model substrate. In addition to their potential use as a bio-mimic catalyst in catechol oxidation,the interaction of all the complexes with proteins (BSA) was also studied to establish their potent role as metal-drug system.