An integrated alcoholic index using tunable-Q wavelet transform based features extracted from EEG signals for diagnosis of alcoholism

Abstract

Alcoholism affects the structure and functioning of brain. Electroencephalogram (EEG) signals can depict the state of brain. The EEG signals are ensemble of various neuronal activity recorded from different scalp regions having different characteristics and very low magnitude in microvolts. These factors make human interpretation difficult and time consuming to analyze these signals. Moreover, these highly varying EEG signals are susceptible to inter/intra variability errors. So, a Computer-Aided Diagnosis (CAD) can be used to identify the alcoholic and normal subjects accurately. However, these EEG signals exhibit nonlinear and non-stationary properties. Therefore, it needs much effort in deciphering the diagnostic evidence from them using linear time and frequency-domain methods. The nonlinear parameters together with time-frequency/scale domain methods can help to detect tiny changes in these signals. The correntropy is nonlinear indicator which characterizes the dynamic behavior of EEG signals in time-scale domain. In this paper, we present a new way for diagnosis of alcoholism using Tunable-Q Wavelet Transform (TQWT) based features derived from EEG signals. The feature extraction is performed using TQWT based decomposition and extracted Centered Correntropy (CC) from the forth decomposed detail sub-band. The Principal Component Analysis (PCA) is used for feature reduction followed by Least Squares-Support Vector Machine (LS-SVM) for classifying normal and alcoholic EEG signals. In order to make sure reliable classification performance, 10-fold cross-validation scheme is adopted. Our proposed system is able to diagnose the alcoholic and normal EEG signals, with an average accuracy of 97.02%, sensitivity of 96.53%, specificity of 97.50% and Matthews correlation coefficient of 0.9494 for Q-factor (Q) varying between 3 and 8 using Radial Basis Function (RBF) kernel function. Also, we have established a novel Alcoholism Risk Index (ARI) using three clinically significant features to discriminate the given classes by means of a single number. This system can be used for automated diagnosis and monitoring of alcoholic subjects to evaluate the effect of treatment. © 2016 Elsevier B.V.