Fe3O4 nanoparticle : an efficient recyclable catalyst for the friedel-crafts reaction of indoles with isoquinoline-1,3,4-trione in water

Abstract

A green, convenient and efficient procedure has been developed for the synthesis of hydroxyindole derivatives. Magnetically separable and recyclable nanoparticles are used as a heterogeneous catalyst for the synthesis of indoles via the one-pot Friedel– Crafts reaction with isoquinoline -1,3,4-trione . Interestingly, indole derivatives are regioselectively acylated in the 3-position under mild conditions, short reaction times high yields with the green aspects by avoiding toxic catalysts. The catalyst could be easily separated from the reaction mixture by using an external magnet and recycled. These operational simple procedures furnish good to high yields of corresponding synthetically as well as biologically interesting functionalized 4-hydroxy-4- indolylisoquinoline-1,3(2H,4H)- diones.