Surfactant-Induced Self-Assembly of CdTe Quantum Dots into Multicolor Luminescent Hybrid Vesicles

Abstract

Here, we report the interaction of mercaptosuccinic acid (MSA)-capped CdTe quantum dots (QDs) with hexadecyltrimethylammonium bromide (CTAB) surfactant and subsequent formation of self-assembled multicolor luminescent vesicles in aqueous medium. A continuous phase sequence from clear (C1) to turbid (T1), precipitate (P), turbid (T2), and clear (C2) has been observed for QD solution upon increasing the concentration of positively charged CTAB, indicating dynamic equilibrium between various self-assembled supramolecular structures. In contrast, no such changes have been observed in the presence of negatively charged sodium dodecyl sulfate and neutral Triton X-100 surfactants, indicating specific electrostatic interactions behind the observed phase separation behavior. Epi-fluorescence imaging in the C1 and C2 regions reveals the presence of surfactant-induced aggregates of QD. The morphologies and photoluminescence properties of self-assembled supramolecular structures in the T1 and T2 region have been explored by using scanning electron microscopy (SEM), atomic force microscopy (AFM), and confocal laser scanning microscopy (CLSM). SEM and AFM images reveal distinct spherical vesicles in the T1 and T2 regions of the binary mixture. Moreover, CLSM results show that these spherical vesicles are inherently luminescent due to the presence of self-assembled QDs. Fabrication of multicolor luminescent vesicles has been demonstrated by tuning the size of CdTe QD. Using CLSM, we have further demonstrated efficient encapsulation of Rhodamine 6G dye into these self-assembled vesicles without any structural disruption. While these luminescent vesicles are quite stable in neutral and basic pH (pH = 6.5-11), they are unstable in acidic pH (pH = 4.5-5.5). Moreover, it has been observed that this pH-responsive structural change is totally reversible. The present findings of self-assembled luminescent vesicles from QD-CTAB binary mixture may open up new opportunities in various applications such as bioimaging, drug delivery, and sensing. © 2019 American Chemical Society.