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| Title: | A novel mesoionic carbene based highly fluorescent Pd(ii) complex as an endoplasmic reticulum tracker in live cells |
| Authors: | Ansari, Shagufi Naz Mobin, Shaikh M. |
| Keywords: | Cell membranes;Fluorescence;Neurodegenerative diseases;Organic compounds;Probes;Synthesis (chemical);Endoplasmic reticulum;Mesoionic carbene;N-heterocyclic;Neurodegeneration;Neurotrauma;Non-toxic;Pd complex;Therapeutic treatments;Palladium compounds;carbene;coordination compound;fluorescent dye;methane;palladium;analogs and derivatives;cell survival;chemical structure;chemistry;confocal microscopy;endoplasmic reticulum;HeLa cell line;human;spectrofluorometry;synthesis;Cell Survival;Coordination Complexes;Endoplasmic Reticulum;Fluorescent Dyes;HeLa Cells;Humans;Methane;Microscopy, Confocal;Molecular Structure;Palladium;Spectrometry, Fluorescence |
| Issue Date: | 2018 |
| Publisher: | Royal Society of Chemistry |
| Citation: | Verma, S. K., Kumari, P., Ansari, S. N., Ansari, M. O., Deori, D., & Mobin, S. M. (2018). A novel mesoionic carbene based highly fluorescent pd(ii) complex as an endoplasmic reticulum tracker in live cells. Dalton Transactions, 47(44), 15646-15650. doi:10.1039/C8DT02778A |
| Abstract: | A recent study advocates that endoplasmic reticulum (ER) dysfunction may be linked to critical neurotrauma and advanced tauopathy. In this regard, targeting the ER warrants urgent attention towards the therapeutic treatment of neurotrauma-related neurodegeneration. Herein, we report the synthesis of a new N-heterocyclic mesoionic carbene based highly fluorescent square-planar Pd(ii) complex 1, with a high quantum yield (0.737). Probe 1 is a non-toxic probe for selectively labeling the endoplasmic reticulum in live cells. © The Royal Society of Chemistry. |
| URI: | https://doi.org/10.1039/C8DT02778A https://dspace.iiti.ac.in/handle/123456789/9060 |
| ISSN: | 1477-9226 |
| Type of Material: | Journal Article |
| Appears in Collections: | Department of Chemistry |
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