Please use this identifier to cite or link to this item: https://dspace.iiti.ac.in/handle/123456789/9220
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dc.contributor.authorKonda, Maruthien_US
dc.contributor.authorBiswas, Sagaren_US
dc.contributor.authorDas, Apurba Kumaren_US
dc.date.accessioned2022-03-17T01:00:00Z-
dc.date.accessioned2022-03-21T11:31:41Z-
dc.date.available2022-03-17T01:00:00Z-
dc.date.available2022-03-21T11:31:41Z-
dc.date.issued2016-
dc.identifier.citationRasale, D. B., Konda, M., Biswas, S., & Das, A. K. (2016). Controlling peptide self-assembly through a native chemical Ligation/Desulfurization strategy. Chemistry - an Asian Journal, 11(6), 926-935. doi:10.1002/asia.201501458en_US
dc.identifier.issn1861-4728-
dc.identifier.otherEID(2-s2.0-84976217336)-
dc.identifier.urihttps://doi.org/10.1002/asia.201501458-
dc.identifier.urihttps://dspace.iiti.ac.in/handle/123456789/9220-
dc.description.abstractSelf-assembled peptides were synthesized by using a native chemical ligation (NCL)/desulfurization strategy that maintained the chemical diversity of the self-assembled peptides. Herein, we employed oxo-ester-mediated NCL reactions to incorporate cysteine, a cysteine-based dipeptide, and a sterically hindered unnatural amino acid (penicillamine) into peptides. Self-assembly of the peptides resulted in the formation of self-supporting gels. Microscopy analysis indicated the formation of helical nanofibers, which were responsible for the formation of gel matrices. The self-assembly of the ligated peptides was governed by covalent and non-covalent interactions, as confirmed by FTIR, CD, fluorescence spectroscopy, and MS (ESI) analyses. Peptide disassembly was induced by desulfurization reactions with tris(2-carboxyethyl)phosphine (TCEP) and glutathione at 80 °C. Desulfurization reactions of the ligated peptides converted the Cys and penicillamine functionalities into Ala and Val moieties, respectively. The self-supporting gels showed significant shear-thinning and thixotropic properties. Energy gels: Self-assembling peptides were synthesized through a native chemical ligation/desulfurization strategy, which resulted in the formation of self-supporting gels that showed shear-thinning and thixotropic properties. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.en_US
dc.language.isoenen_US
dc.publisherJohn Wiley and Sons Ltden_US
dc.sourceChemistry - An Asian Journalen_US
dc.subjectAmino acidsen_US
dc.subjectDesulfurizationen_US
dc.subjectFluorescence spectroscopyen_US
dc.subjectFourier transform infrared spectroscopyen_US
dc.subjectGelsen_US
dc.subjectNon Newtonian flowen_US
dc.subjectPhosphorus compoundsen_US
dc.subjectSelf assemblyen_US
dc.subjectShear flowen_US
dc.subjectShear thinningen_US
dc.subjectDesulfurization reactionen_US
dc.subjectNative chemical ligationen_US
dc.subjectNon-covalent interactionen_US
dc.subjectPeptide self assembliesen_US
dc.subjectSelf-assembled peptidesen_US
dc.subjectSelf-assembling peptidesen_US
dc.subjectThixotropic propertiesen_US
dc.subjectTris(2-carboxyethyl) phosphineen_US
dc.subjectPeptidesen_US
dc.subjectpeptideen_US
dc.subjectsulfuren_US
dc.subjectchemistryen_US
dc.subjectcircular dichroismen_US
dc.subjectelectrospray mass spectrometryen_US
dc.subjectspectrofluorometryen_US
dc.subjectCircular Dichroismen_US
dc.subjectPeptidesen_US
dc.subjectSpectrometry, Fluorescenceen_US
dc.subjectSpectrometry, Mass, Electrospray Ionizationen_US
dc.subjectSulfuren_US
dc.titleControlling Peptide Self-Assembly through a Native Chemical Ligation/Desulfurization Strategyen_US
dc.typeJournal Articleen_US
Appears in Collections:Department of Chemistry

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