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DC Field | Value | Language |
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dc.contributor.author | Konda, Maruthi | en_US |
dc.contributor.author | Biswas, Sagar | en_US |
dc.contributor.author | Das, Apurba Kumar | en_US |
dc.date.accessioned | 2022-03-17T01:00:00Z | - |
dc.date.accessioned | 2022-03-21T11:31:41Z | - |
dc.date.available | 2022-03-17T01:00:00Z | - |
dc.date.available | 2022-03-21T11:31:41Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Rasale, D. B., Konda, M., Biswas, S., & Das, A. K. (2016). Controlling peptide self-assembly through a native chemical Ligation/Desulfurization strategy. Chemistry - an Asian Journal, 11(6), 926-935. doi:10.1002/asia.201501458 | en_US |
dc.identifier.issn | 1861-4728 | - |
dc.identifier.other | EID(2-s2.0-84976217336) | - |
dc.identifier.uri | https://doi.org/10.1002/asia.201501458 | - |
dc.identifier.uri | https://dspace.iiti.ac.in/handle/123456789/9220 | - |
dc.description.abstract | Self-assembled peptides were synthesized by using a native chemical ligation (NCL)/desulfurization strategy that maintained the chemical diversity of the self-assembled peptides. Herein, we employed oxo-ester-mediated NCL reactions to incorporate cysteine, a cysteine-based dipeptide, and a sterically hindered unnatural amino acid (penicillamine) into peptides. Self-assembly of the peptides resulted in the formation of self-supporting gels. Microscopy analysis indicated the formation of helical nanofibers, which were responsible for the formation of gel matrices. The self-assembly of the ligated peptides was governed by covalent and non-covalent interactions, as confirmed by FTIR, CD, fluorescence spectroscopy, and MS (ESI) analyses. Peptide disassembly was induced by desulfurization reactions with tris(2-carboxyethyl)phosphine (TCEP) and glutathione at 80 °C. Desulfurization reactions of the ligated peptides converted the Cys and penicillamine functionalities into Ala and Val moieties, respectively. The self-supporting gels showed significant shear-thinning and thixotropic properties. Energy gels: Self-assembling peptides were synthesized through a native chemical ligation/desulfurization strategy, which resulted in the formation of self-supporting gels that showed shear-thinning and thixotropic properties. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. | en_US |
dc.language.iso | en | en_US |
dc.publisher | John Wiley and Sons Ltd | en_US |
dc.source | Chemistry - An Asian Journal | en_US |
dc.subject | Amino acids | en_US |
dc.subject | Desulfurization | en_US |
dc.subject | Fluorescence spectroscopy | en_US |
dc.subject | Fourier transform infrared spectroscopy | en_US |
dc.subject | Gels | en_US |
dc.subject | Non Newtonian flow | en_US |
dc.subject | Phosphorus compounds | en_US |
dc.subject | Self assembly | en_US |
dc.subject | Shear flow | en_US |
dc.subject | Shear thinning | en_US |
dc.subject | Desulfurization reaction | en_US |
dc.subject | Native chemical ligation | en_US |
dc.subject | Non-covalent interaction | en_US |
dc.subject | Peptide self assemblies | en_US |
dc.subject | Self-assembled peptides | en_US |
dc.subject | Self-assembling peptides | en_US |
dc.subject | Thixotropic properties | en_US |
dc.subject | Tris(2-carboxyethyl) phosphine | en_US |
dc.subject | Peptides | en_US |
dc.subject | peptide | en_US |
dc.subject | sulfur | en_US |
dc.subject | chemistry | en_US |
dc.subject | circular dichroism | en_US |
dc.subject | electrospray mass spectrometry | en_US |
dc.subject | spectrofluorometry | en_US |
dc.subject | Circular Dichroism | en_US |
dc.subject | Peptides | en_US |
dc.subject | Spectrometry, Fluorescence | en_US |
dc.subject | Spectrometry, Mass, Electrospray Ionization | en_US |
dc.subject | Sulfur | en_US |
dc.title | Controlling Peptide Self-Assembly through a Native Chemical Ligation/Desulfurization Strategy | en_US |
dc.type | Journal Article | en_US |
Appears in Collections: | Department of Chemistry |
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