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| Title: | Regiospecific synthesis of arenofurans via cascade reactions of arenols with Morita-Baylis-Hillman acetates of nitroalkenes and total synthesis of isoparvifuran |
| Authors: | Mobin, Shaikh M. |
| Keywords: | 1 naphthol;2 naphthol;acetic acid derivative;alkene derivative;antifungal agent;arenofuran derivative;furan derivative;isoparvifuran;Morita Baylis Hillman acetate;nitroalkene derivative;phenol derivative;unclassified drug;article;methodology;Michael addition;priority journal;synthesis |
| Issue Date: | 2013 |
| Citation: | Kumar, T., Mobin, S. M., & Namboothiri, I. N. N. (2013). Regiospecific synthesis of arenofurans via cascade reactions of arenols with morita-baylis-hillman acetates of nitroalkenes and total synthesis of isoparvifuran. Tetrahedron, 69(24), 4964-4972. doi:10.1016/j.tet.2013.04.023 |
| Abstract: | A cascade process involving an SN2′ reaction and an intramolecular oxa-Michael addition has been developed by treating Morita-Baylis-Hillman acetates of nitroalkenes with arenols, such as β-naphthols, α-naphthols, and substituted phenols under basic conditions. The products, arenofurans, are formed as single regioisomers in good to excellent yield in most cases. The methodology has been successfully employed for the total synthesis of an anti fungal agent isoparvifuran. © 2013 Elsevier Ltd. All rights reserved. |
| URI: | https://doi.org/10.1016/j.tet.2013.04.023 https://dspace.iiti.ac.in/handle/123456789/9427 |
| ISSN: | 0040-4020 |
| Type of Material: | Journal Article |
| Appears in Collections: | Department of Chemistry |
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