9-Anthracenemethoxycarbonyl protected dipeptide-based soft materials for biomedical applications

Abstract

Peptide self-assembly has been extensively investigated for the preparation of functional biomaterials that can be used for the various interdisciplinary areas of research which include antibacterial therapy, wound healing, drug delivery and tissue engineering. The low-molecular-weight peptide-based hydrogels have attracted significant attentions in the area of biomedical research because of their biocompatibility, non-immunogenicity, biodegradability, and chemical simplicity. In the thesis work, the Amoc (9-anthracenemethoxycarbonyl)-capped dipeptides have been designed and synthesized which self-assemble into the water and form hydrogels owing to the participation of noncovalent interactions. The synthesized hydrogels have been employed for various in vitro and in vivo biological applications. The main objectives of the present study are: 1. To design and synthesize the Amoc-capped dipeptide-based biocompatible and injectable hydrogels for the differential biological effect on bacterial and human blood cells. 2. To design and synthesize an Amoc-capped dipeptide-based hydrogel which show anti-inflammatory activity on rat air pouch model of acute inflammation. 3. To design and synthesize an Amoc-capped dipeptide-based coassembled nanofibrous and thixotropic hydrogel for dermal wound healing. 4. To design and synthesize an Amoc-capped dipeptide-based coassembled hydrogel for in vivo wound dressing application.