Design, synthesis and characterization of 1,2,3-triazole based compounds

Abstract

The work described in this thesis concerns the synthesis of series of novel 1,2,3-triazole based compounds. The triazole based compounds 4-(4-ethynylphenyl)-1-methyl-1H-1,2,3-triazole (L1), 4,4'-(5'-(4-(1-propyl-1H-1,2,3-triazol-4-yl)phenyl)-[1,1':3',1''-terphenyl]-4,4''-diyl)bis(1-propyl-1H-1,2,3-triazole) (L2) and 1,3,5-tris(1-(pyridin-3-ylmethyl)-1H-1,2,3-triazol-4-yl)benzene (L3) were synthesized by Cu(I)-catalyzed azide alkyne cycloadditon reaction (Known as click reaction) of 1,4-diethynyl benzene with methyliodide, 4,4''-diethynyl-5'-(4-ethynylphenyl)-1,1':3',1''-terphenyl with 1-bromopropane and 1,3,5-triethynylbenzene with 2-(bromomethyl)pyridine in presence of sodium azide respectively. This compounds have been characterized by NMR spectroscopy and Mass spectrometry.