Development of efficient and metal-free one-pot sequential strategy for synthesis of functionalized pyridine and related scaffolds

Abstract

This thesis presents development of a metal free efficient approach to synthesize poly-functionalized nicotinic acid (Pyridine-3-carboxylicacid) derivative by using N-sulfonyl ketimines as 1,3 bi-nucleophile and MBH carbonate of ethyl acrylate as 1,3 bi-electrophile. The design and development of an efficient synthetic protocol for the access to a series of synthetically and biologically important molecules from easily available starting materials using a metal free condition is the fastest growing era of modern organic chemistry. For their vast applications several reports are there for their synthesis. Here we have developed a metal free one pot sequential approach to synthesize nicotinate derivative with a moderate condition with efficient yield. We have used N-sulfonyl ketimines as bi-nucleophile and MBH carbonate as bi-electrophile.