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https://dspace.iiti.ac.in/handle/123456789/11684
| Title: | Gelatin-Coated Copper-Based Metal-Organic Framework for Controlled Insulin Delivery: Possibility toward Oral Delivery System |
| Authors: | Kumar, Pawan Kaur, Navpreet Tiwari, Pranav Gupta, Anoop K. Mobin, Shaikh M. |
| Keywords: | Metal-Organic Frameworks;Pore size;Synthesis (chemical);Brunauer-emmett-teller surface areas;Copper-based;Crystal system;Delivery systems;Insulin delivery;Metalorganic frameworks (MOFs);Oral delivery;Pyridine-2;Space Groups;Tetragonal crystals;Insulin |
| Issue Date: | 2023 |
| Publisher: | American Chemical Society |
| Citation: | Kumar, P., Kaur, N., Tiwari, P., Gupta, A. K., & Mobin, S. M. (2023). Gelatin-coated copper-based metal-organic framework for controlled insulin delivery: Possibility toward oral delivery system. ACS Materials Letters, , 1100-1108. doi:10.1021/acsmaterialslett.2c01175 |
| Abstract: | The development of nontoxic, hemocompatible materials for controlled insulin delivery is a great challenging task for researchers. Herein, we demonstrate the design of a novel linker 5,5′-((pyridine-2,6-diylbis(methylene)) bis(oxy))diisophthalic acid (H4L) and its utilization to synthesize a new Cu-MOF (IITI-3). IITI-3 crystallizes in a tetragonal crystal system with space group I4/mmm and shows a high Brunauer-Emmett-Teller (BET) surface area of 1026.5 m2/g with pore diameter (Barrett-Joyner-Halenda pore size distribution) of 3.413 nm. The IITI-3 is found to be stable in the biological fluid pH ranges from 3 to 10. Moreover, IITI-3 were explored for insulin delivery by coating the IITI-3 with gelatin (gel@insIITI-3) the overall insulin was controlled from the framework. The obtained result paves a new avenue for the oral delivery of insulin using the IITI-3 metal-organic framework. © 2023 American Chemical Society. |
| URI: | https://doi.org/10.1021/acsmaterialslett.2c01175 https://dspace.iiti.ac.in/handle/123456789/11684 |
| ISSN: | 2639-4979 |
| Type of Material: | Journal Article |
| Appears in Collections: | Department of Biosciences and Biomedical Engineering Department of Chemistry |
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