Synthesis of heterocycles for treatment of tuberculosis

Abstract

Tuberculosis is a deadly infectious disease caused by the bacterium called Mycobacterium tuberculosis. To eradicate Mtb, the synthesis of potent drugs that are capable to overcome drug-resistant tuberculosis is vital. A rapid increase in the drug-resistant nature of Mtb is mainly due to the complex and multilayered nature of the cell wall of Mtb. Furo[3,2- c]pyridines, 5-azaindoles and thieno[3,2-c]pyridines are promising moieties to inhibit polyketide synthase 13 (PKs13), an enzyme involved in the biosynthesis of mycolic acid present in the cell wall of Mtb. The present thesis describes the synthesis of furo[3,2-c]pyridines, 5-azaindoles and thieno[3,2-c]pyridine hybrids, which may act as competitive inhibitors of polyketide synthase 13 (Pks13), an enzyme involved in the synthesis of mycolic acid of the bacterial cell wall. Further, these compounds are examined for the treatment of MDR and XDR tuberculosis currently.