Developing a synergistic combination of an anti-inflammatory compound and a broad-range antibiotic as an effective therapy for sepsis

Abstract

Sepsis is a multi-organ dysfunction condition brought on by uncontrolled inflammation after a pathogenic infection. The pathogen or cytokines are first released into the bloodstream by diseased or injured tissue. The blood contains a range of cells that might induce inflammation, such as neutrophils, natural killer cells, and, most notably, macrophages. The proposed therapeutic strategy against sepsis is based on a novel drug combination. We propose a novel synergistic combination of a broad spectrum antibiotic and repurposed anti-inflammatory drug Repurposed Drug. Antibiotic not only can kill a broad range of bacterial species but could also control chronic inflammation in the host by preventing the activation of TIRAP, which is necessary for the induction of key inflammatory signaling events. In our previous studies, Repurposed Drug has already been repurposed to target TIRAP and inhibit its activation. Our in vivo studies not only suggest but validate our hypothesis that combined Antibiotic and Repurposed Drug preparation shows high potency in a septic mouse model. This novel combination therapy is a promising strategy for the treatment of severe sepsis.