Design and synthesis of metalorganic framework and its biomedical applications

Abstract

Over the past decades, the usage of metal-organic frameworks (MOFs) in biomedical applications has increased significantly because these materials have high loading capacities, high surface areas, and precision tunability. Moreover, a wide range of drug delivery applications are being investigated for MOFs. Herein, we have synthesized copper-based MOFs (IITI-3) which were characterized by using PXRD, TGA, BET, IR, and UV techniques. In this study, we have analyzed the effective delivery of two drugs using IITI-3: Ibuprofen and Curcumin. Brunauer-Emmett-Teller (BET) analysis affirmed the IITI-3’s suitability as a carrier, demonstrating its ability to accommodate multiple drugs simultaneously. Interestingly, while simultaneous loading of both drugs was successful, individual drug loading experiments revealed selective encapsulation of only Curcumin within IITI-3. The pH-dependent release of the encapsulated drugs was validated by further release investigations employing UV spectroscopy at pH 7.4 and 5.8, which represent physiological and second intestine pH respectively. This pH-responsive behavior has potential use in targeted drug administration, especially in conditions similar to second intestine pH