Investigating the Epstein Barr virus-mediated perturbations and entry mechanism in brain cells: an insight into neuropathologies

Abstract

The Herpesviridae family entails more than 130 viruses that are known to infect mammals, birds, fish, reptiles, amphibians, and even molluscs. Herpesviridae subfamilies like alpha (α), beta (β), and gamma (γ) are known to infect humans, and they are categorised based on their replication strategies, host range and genetic organisation [1]. Herpesviruses are so ubiquitous that one or more herpesviruses infect almost all humans during their lifespan. Epstein Barr virus (EBV) is a member of the human γ-herpesvirus family, and it establishes its latency for a long period in B-cells, and their reactivation instigates and/or aggravates dreadful diseases from cancer to neurological modalities, i.e., Multiple Sclerosis (MS) and Alzheimer’s disease (AD)