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Title: | Visible light-induced photo-redox catalysis and dual catalysis for C–H functionalization of 2-phenyl-4H-pyrido[1,2-a] pyrimidin-4-one and 2-aryl heterocycles |
Authors: | Tabajee, Bhawale Rajesh |
Supervisors: | Kshirsagar, Umesh A. |
Keywords: | Chemistry |
Issue Date: | 7-May-2025 |
Publisher: | Department of Chemistry, IIT Indore |
Series/Report no.: | TH710; |
Abstract: | This thesis aims to investigate the potential of modern advancements in carbon-carbon (C–C) bond formation, with a specific emphasis on C–H activation and functionalization facilitated by visible light-mediated photo-redox catalysis and transition metal catalysis. These innovative strategies enable the construction of C–C bonds under mild conditions, typically at room temperature, offering a greener and more sustainable approach to synthetic transformations. In Chapter 1, we introduced the literature study of coupling reactions, particularly for C-C bond formation facilitated by transition metal catalysts. This discussion was extended to include visible-light photoinduced pathways for C-H functionalization, highlighting their growing significance in modern organic synthesis. Furthermore, advanced methodologies that integrate photocatalysis with transition metal catalysis to achieve efficient C-C bond formation, emphasizing their innovative potential have been discussed. Finally, we briefly discussed the importance of 2-phenyl-4H-pyrido[1,2-a]pyrimidin-4-one and reviewed previous reports on the synthesis and functionalization of 2-phenyl-4H-pyrido[1,2-a]pyrimidin-4-one, providing a foundation for further exploration in this area. Current thesis work focuses on the regio-selective C–H activation and subsequent functionalization, such as arylation, acylation, alkylation, and alkenylation of 2-Phenyl-4H-pyrido[1,2-a]pyrimidin-4-one and related heterocycles under visible light photo-redox catalytic conditions or through the synergistic merging of photo-redox with transition metal catalysis. |
URI: | https://dspace.iiti.ac.in:8080/jspui/handle/123456789/16442 |
Type of Material: | Thesis_Ph.D |
Appears in Collections: | Department of Chemistry_ETD |
Files in This Item:
File | Description | Size | Format | |
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TH_710_Bhawale_Rajesh_Tabajee_1901231016.pdf | 10.69 MB | Adobe PDF | View/Open |
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