Cu-catalyzed domino route to imidazo[1,2-a] pyridines

Abstract

A new route to imidazo[1,2-a]pyridines by using copper-catalyzed one-pot reaction of oxime acetates with 2-aminopyridines has been demonstrated. The importance of the present protocol is (1) low cost catalyst loading; (2) easily available starting materials; and (3) absence of stoichiometric external oxidants. Hence, this domino strategy provides an excellent alternative over previous approaches in the synthesis of imidazo[1,2-a]pyridines.