Magnetic Nanoparticles: A Green Catalyst for the Synthesis of Isoxazole Scaffolds (A Review)

Abstract

Abstract: In organic synthesis, environmentally friendly reactions have special and critical features. With more eco-friendly and green methods for different organic transformations, considerable development has been achieved recently. In the context of green synthesis, MNPs as a green catalyst attract major attention. Different heterocycles have been synthesized using MNPs as green catalysts. Among heterocycles, isoxazole is a privileged scaffold and it provided multiple lead structures for the development of therapeutic candidates. The utilisation of MNPs as catalyst significantly enhances the demand for isoxazole synthesis. Consequently, there is a pressing and future necessity to generate an increasing number of isoxazole derivatives by using green synthetic methods. This article presents an updated report on the role of MNPs green catalysts in the development of a diverse array of isoxazoles. © Pleiades Publishing, Ltd. 2025.