Magnetic nanoparticles: A green catalyst towards the development of oxazole scaffolds

Abstract

Environment-friendly reactions in organic synthesis have a special and inimitable position. Regarding more ecological and sustainable methods for different organic transformations, there has been notable advancement in the past. In this regard, magnetic nanoparticles draw a lot of interest within the framework of green synthesis. MNPs have been applied as a green catalyst in green synthesis to produce several heterocycles. Oxazole is regarded as a popular and quite useful motif among aza-heterocycles. It offered various lead structures for the development of drug candidates. Using MNPs as a green catalyst increases the demand for the development of oxazole based molecular architectures. Therefore, it is indeed a future demand to develop more and more derivatives of oxazole via green synthetic methodology. Thus, this work provides a first report (from 2015 to present) on the function of green catalysts as MNPs in producing a wide range of privileged oxazole derivatives. © 2026 Vietnam Academy of Science and Technology and Wiley-VCH GmbH.