Photocatalytic Silacyclization of 1,7-Enynes via Selective Functionalization of Si-H/Silyl C(sp3)-H Bonds: Access to Densely Functionalized Silacycles

Abstract

We report a highly efficient protocol for the synthesis of silacycles through oxidative annulation cascade with 1,7-enynes via selective functionalization of Si-H/silyl C(sp3)-H bonds of hydrosilanes. Simple N-aminopyridinium salt acts as hydrogen atom transfer reagents for the in situ generation of sulfamidyl radical under photoredox catalytic condition. Notably, this protocol demonstrates broad substrate scope with shorter reaction time and viable to the late-stage functionalization of natural products and pharmaceuticals. © 2026 Wiley-VCH GmbH.