C-H functionalization of heterocycles through radical process

Abstract

Direct functionalization at the C3-site of Quinoxalin-2(1H)-one via oxidative addition of silyl radicals has been studied. Broad range of biological activities and pharmaceutical applications of C3-incorporated Quinoxalin-2(1H)-one has paved a way for the large advancement in the selective introduction of range of radicals for the new C-C, C-O, C-N, C P, C-O and C-S linkage incorporations. In this work, a bond between silyl group andC3-carbon of Quinoxalin-2(1H)-one is entrenched under mild to tolerant oxidative reaction environment.