Base-promoted reaction of unsaturated N-Sulfonyl ketimines with sulfer Ylides: access to cyclopropane and pyrrole rings

Abstract

Pyrrole and cyclopropane rings are present ubiquitously in biologically active natural molecules, pharmaceutical and drug molecules etc. So, the establishment of unprecedented tactics for the synthesis of interesting functionalized cyclopropane and pyrrole scaffolds is a pivotal research target for chemists. Towards the above goal, herein we have developed an efficient base-promoted [2+1] and [4+1] cyclization reaction of cyclic 1-azadienes with sulfur ylides. The above Michael initiated ring closing process affords vital classes of cyclopropane and pyrrole moieties with acceptable chemical yields.