Synthesis and characterization of amino acid functionalized silver nanoparticles and their interaction with lipid membrane

Abstract

The effect of the nature of the bare NPs surface in presence of the same ligands in the lipid bilayer and nanoparticles interaction (lipid corona formation) is not well studied in the literature. Therefore, we are interested to study the intermixing of the amino acid functionalized gold and silver nanoparticles with the lipid bilayer. In the present contribution, we have synthesized aromatic amino acid functionlized silver nanoparticles to look into the intermixing of these with the lipid membrane and compare this with our previous results with amino acid functionalized gold nanoparticles. Firstly, both the concentration of sodium hydroxide and amino acids play a crucial part in the formation of colloidal stable silver nanoparticles, These silver nanoparticles have well fluorescence properties because of clusterization of the amino acids on the NPs plane. The Ag-Tyr NPs at low lipid measurement of zwitterionic lipid vesicles are stable which is opposite to our previous results for Au-Tyr NPs. This specifies the part of bare NPs plane important part in the NPs and lipid bilayer interaction.