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| Title: | Mitochondrial mutations and genetic factors determining nafld risk |
| Authors: | Baig, Mirza Saqib |
| Keywords: | biological marker;cryopyrin;inflammasome;mitochondrial DNA;reactive oxygen metabolite;mitochondrial DNA;allele;carcinogenesis;chronic inflammation;diabetes mellitus;disease association;disease exacerbation;disorders of mitochondrial functions;fatty acid oxidation;gene;gene function;gene identification;gene mutation;genetic risk;glucose metabolism;hepatitis;heredity;human;immune response;inflammation;lipid metabolism;lipotoxicity;liver cell carcinoma;liver cirrhosis;liver mitochondrion;mitochondrial respiration;mitophagy;nonalcoholic fatty liver;nonalcoholic steatohepatitis;nonhuman;oxidative stress;pathogenesis;patient care;pnpla3 gene;Review;single nucleotide polymorphism;urea cycle;animal;genetics;metabolism;mitochondrion;mutation;nonalcoholic fatty liver;pathology;risk factor;Animals;Disease Progression;DNA, Mitochondrial;Humans;Mitochondria;Mutation;Non-alcoholic Fatty Liver Disease;Polymorphism, Single Nucleotide;Risk Factors |
| Issue Date: | 2021 |
| Publisher: | MDPI |
| Citation: | Dabravolski, S. A., Bezsonov, E. E., Baig, M. S., Popkova, T. V., Nedosugova, L. V., Starodubova, A. V., & Orekhov, A. N. (2021). Mitochondrial mutations and genetic factors determining nafld risk. International Journal of Molecular Sciences, 22(9) doi:10.3390/ijms22094459 |
| Abstract: | NAFLD (non-alcoholic fatty liver disease) is a widespread liver disease that is often linked with other life-threatening ailments (metabolic syndrome, insulin resistance, diabetes, cardiovascular disease, atherosclerosis, obesity, and others) and canprogress to more severe forms, such as NASH (non-alcoholic steatohepatitis), cirrhosis, and HCC (hepatocellular carcinoma). In this review, we summarized and analyzed data about single nucleotide polymorphism sites, identified in genes related to NAFLD development and progression. Additionally, the causative role of mitochondrial mutations and mitophagy malfunctions in NAFLD is discussed. The role of mitochondria-related metabolites of the urea cycle as a new non-invasive NAFLD biomarker is discussed. While mitochondria DNA mutations and SNPs (single nucleotide polymorphisms) canbe used as effective diagnostic markers and target for treatments, age and ethnic specificity should be taken into account. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
| URI: | https://doi.org/10.3390/ijms22094459 https://dspace.iiti.ac.in/handle/123456789/3866 |
| ISSN: | 1661-6596 |
| Type of Material: | Review |
| Appears in Collections: | Department of Biosciences and Biomedical Engineering |
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