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| Title: | NOS1 mediates AP1 nuclear translocation and inflammatory response |
| Authors: | Srivastava, Mansi Baig, Mirza Saqib |
| Keywords: | activating transcription factor 2;immunoglobulin enhancer binding protein;interleukin 8;neuronal nitric oxide synthase;nitric oxide;nitric oxide synthase;nitrite;protein c jun;protein fos;synaptotagmin I;toll like receptor 4;transcription factor AP 1;autacoid;cytokine;inducible nitric oxide synthase;interleukin 1 receptor;lipopolysaccharide;membrane protein;neuronal nitric oxide synthase;nitric oxide;protein c jun;TIRAP protein, mouse;transcription factor AP 1;animal cell;animal experiment;animal model;Article;bone marrow derived macrophage;controlled study;cytokine response;enzyme inhibition;gene control;immune response;inflammation;macrophage;mouse;nonhuman;priority journal;protein expression;protein protein interaction;protein transport;quantitative analysis;animal;cell nucleus;drug effect;gene expression regulation;inflammation;metabolism;pathology;protein subunit;protein transport;Animals;Cell Nucleus;Cytokines;Gene Expression Regulation;Inflammation;Inflammation Mediators;Lipopolysaccharides;Macrophages;Membrane Glycoproteins;Mice;Nitric Oxide;Nitric Oxide Synthase Type I;Nitric Oxide Synthase Type II;Protein Subunits;Protein Transport;Proto-Oncogene Proteins c-jun;Receptors, Interleukin-1;Transcription Factor AP-1 |
| Issue Date: | 2018 |
| Publisher: | Elsevier Masson SAS |
| Citation: | Srivastava, M., & Baig, M. S. (2018). NOS1 mediates AP1 nuclear translocation and inflammatory response. Biomedicine and Pharmacotherapy, 102, 839-847. doi:10.1016/j.biopha.2018.03.069 |
| Abstract: | A hallmark of the AP1 functioning is its nuclear translocation, which induces proinflammatory cytokine expression and hence the inflammatory response. After endotoxin shock AP1 transcription factor, which comprises Jun, ATF2, and Fos family of proteins, translocates into the nucleus and induces proinflammatory cytokine expression. In the current study, we found, NOS1 inhibition prevents nuclear translocation of the AP1 transcription factor subunits. Pharmacological inhibition of NOS1 impedes translocation of subunits into the nucleus, suppressing the transcription of inflammatory genes causing a diminished inflammatory response. In conclusion, the study shows the novel mechanism of NOS1- mediated AP1 nuclear translocation, which needs to be further explored. © 2018 Elsevier Masson SAS |
| URI: | https://doi.org/10.1016/j.biopha.2018.03.069 https://dspace.iiti.ac.in/handle/123456789/4018 |
| ISSN: | 0753-3322 |
| Type of Material: | Journal Article |
| Appears in Collections: | Department of Biosciences and Biomedical Engineering |
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