Synthesis of nano MOFs and their characterization

Abstract

Metal-organic frameworks (MOFs) are a unique class of hybrid porous solids based on metals and organic linkers. Compared to traditional porous materials, they possess predominance of large surface areas, tunable pore size and shape, adjustable composition and functionalized pore surface, which enable them unique advantages and promises for applications in adsorption and release of therapeutic agents. In the domain of health, one important challenge is the efficient delivery of drugs in the body using non-toxic nanocarriers. The nanosize also allows for access into the cell and various cellular compartments including the nucleus. Most of the existing carrier materials (MOFs) were in micrometer range and/or show poor drug loading (usually less than 5 wt% of the transported drug versus the carrier material) and/or rapid release of the proportion of the drug that is simply adsorbed (or anchored) at the external surface of the nanocarrier. In this context, biocompatible, non-toxic, porous hybrid solids, with the ability to tune their structures and porosities for better drug interactions and high loadings, are studied to serve as nanocarriers for drug delivery.