Please use this identifier to cite or link to this item:
https://dspace.iiti.ac.in/handle/123456789/5381
Title: | Investigation of diseases through red blood cells' shape using photoacoustic response technique |
Authors: | Gorey, Abhijeet Vasudevan, Srivathsan |
Keywords: | Cells;Cytology;Diagnosis;Medical imaging;Mobile security;Morphology;Photoacoustic effect;Time domain analysis;Biological studies;Haematology;Hypertonic solutions;Morphological changes;Photoacoustic techniques;Real-time techniques;Red blood cell;Time-domain signal;Blood |
Issue Date: | 2015 |
Publisher: | SPIE |
Citation: | Biswas, D., Gorey, A., Chen, G. C. K., Sharma, N., & Vasudevan, S. (2015). Investigation of diseases through red blood cells' shape using photoacoustic response technique. Paper presented at the Progress in Biomedical Optics and Imaging - Proceedings of SPIE, , 9322 doi:10.1117/12.2079185 |
Abstract: | Photoacoustic (PA) imaging is a non-invasive real-time technique, widely applied to many biomedical imaging studies in the recent years. While most of these studies have been focussed on obtaining an image after reconstruction, various features of time domain signal (e.g. amplitude, width, rise and relaxation time) would provide very high sensitivity in detecting morphological changes in cells during a biological study. Different haematological disorders (e.g., sickle cell anaemia, thalassemia) exhibit significant morphological cellular changes. In this context, this study explores the possibility of utilizing the developed photoacoustic response technique to apply onto blood samples. Results of our preliminary study demonstrate that there is a significant change in signal amplitude due to change in concentration of the blood. Thus it shows the sensitivity of the developed photoacoustic technique towards red blood cell count (related to haematological disease like anaemia). Subsequently, morphological changes in RBC (i.e. swollen and shrunk compared to normal RBC) induced by hypotonic and hypertonic solutions respectively were also experimented. The result shows a distinct change in PA signal amplitude. This would serve as a diagnostic signature for many future studies on cellular morphological disorders. © 2015 SPIE. |
URI: | https://doi.org/10.1117/12.2079185 https://dspace.iiti.ac.in/handle/123456789/5381 |
ISBN: | 9781628414127 |
ISSN: | 1605-7422 |
Type of Material: | Conference Paper |
Appears in Collections: | Department of Electrical Engineering |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
Altmetric Badge: