Synchronization in multiplex models of neuron-glial systems: Small-world topology and inhibitory coupling

Abstract

In this work, we investigate the impact of mixed coupling on synchronization in a multiplex oscillatory network. The network mimics the neural-glial systems by incorporating interacting slow ("glial") and fast ("neural") oscillatory layers. Connections between the "glial"elements form a regular periodic structure, in which each element is connected to the eight other neighbor elements, whereas connections among "neural"elements are represented by Watts-Strogatz networks (from regular and small-world to random Erdös-Rényi graph) with a matching mean node degree. We find that the random rewiring toward small-world topology readily yields the dynamics close to that exhibited for a completely random graph, in particular, leading to coarse-graining of dynamics, suppressing multi-stability of synchronization regimes, and the onset of Kuramoto-type synchrony in both layers. The duration of transient dynamics in the system measured by relaxation times is minimized with the increase of random connections in the neural layer, remaining substantial only close to synchronization-desynchronization transitions. "Inhibitory"interactions in the "neural"subnetwork layer undermine synchronization; however, the strong coupling with the "glial"layer overcomes this effect. © 2021 Author(s).