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| Title: | Fabrication of innovative ZnO nanoflowers showing drastic biological activity |
| Authors: | Mohammad, Akbar Mishra, Veenu Chaudhary, Archana Mobin, Shaikh M. |
| Keywords: | antiinfective agent;circular DNA;hydrogen peroxide;plasmid DNA;zinc complex;zinc oxide nanoparticle;Article;bacterial strain;bacterial viability;binding affinity;biological activity;cell death;controlled study;DNA cleavage;drug DNA binding;drug structure;drug synthesis;Escherichia coli;fluorescence microscopy;Gram negative bacterium;growth inhibition;high temperature;minimum bactericidal concentration;minimum inhibitory concentration;nanofabrication;nonhuman;one pot synthesis;particle size;priority journal;room temperature |
| Issue Date: | 2016 |
| Publisher: | Royal Society of Chemistry |
| Citation: | Sharma, V., Mohammad, A., Mishra, V., Chaudhary, A., Kapoor, K., & Mobin, S. M. (2016). Fabrication of innovative ZnO nanoflowers showing drastic biological activity. New Journal of Chemistry, 40(3), 2145-2155. doi:10.1039/c5nj02391b |
| Abstract: | The present study deals with the synthesis of ZnO nanoflowers (ZnO-1 and ZnO-2) at room temperature using new structurally characterized single molecular precursors (1 and 2). 1, 2 and ZnO-1 were explored for their potential to reduce the viability of the Gram-negative bacteria Escherichia coli.1 and 2 were found to be promising antibacterial agents, while the ZnO nanoflowers demonstrated a relatively non-toxic nature. 1, 2 and ZnO-1 were further evaluated for DNA binding and cleavage behaviour. 1 and 2 showed strong binding affinity towards CT-DNA compared to ZnO-1. In addition, all the three compounds demonstrated oxidative cleavage of pBluescript plasmid DNA in the presence of H2O2. © The Royal Society of Chemistry and the Centre National de la Recherche Scientifique 2016. |
| URI: | https://doi.org/10.1039/c5nj02391b https://dspace.iiti.ac.in/handle/123456789/9254 |
| ISSN: | 1144-0546 |
| Type of Material: | Journal Article |
| Appears in Collections: | Department of Chemistry |
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