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| Title: | Small animal optical diffusion tomography with targeted fluorescence |
| Authors: | Chelvam, Venkatesh |
| Keywords: | Optics;Diffusion-equation models;Multi-resolutions;Non-linear optimization;Optical diffusion tomography;Optical imaging;Photon transport;Targeted imaging;Unstructured grid;Partial differential equations;algorithm;animal;article;Bayes theorem;equipment;finite element analysis;fluorescence;image processing;image quality;kidney;laser;methodology;mouse;neoplasm;optical tomography;optics;pathology;photon;radiation scattering;reproducibility;surface property;three dimensional imaging;Algorithms;Animals;Bayes Theorem;Finite Element Analysis;Fluorescence;Image Processing, Computer-Assisted;Imaging, Three-Dimensional;Kidney;Lasers;Mice;Neoplasms;Optics and Photonics;Phantoms, Imaging;Photons;Reproducibility of Results;Scattering, Radiation;Surface Properties;Tomography, Optical |
| Issue Date: | 2013 |
| Publisher: | OSA - The Optical Society |
| Citation: | Gaind, V., Tsai, H. -., Webb, K. J., Chelvam, V., & Low, P. S. (2013). Small animal optical diffusion tomography with targeted fluorescence. Journal of the Optical Society of America A: Optics and Image Science, and Vision, 30(6), 1146-1154. doi:10.1364/JOSAA.30.001146 |
| Abstract: | Despite the broad impact in medicine that optics can bring, thus far practical approaches are limited to weak scatter or near-surface monitoring. We show a method that utilizes a laser topography scan and a diffusion equation model to describe the photon transport, together with a multiresolution unstructured grid solution to the nonlinear optimization measurement functional, that overcomes these limitations. We conclude that it is possible to achieve whole body optical imaging with a resolution suitable for finding cancer nodules within an organ during surgery, with the aid of a targeted imaging agent. © 2013 Optical Society of America. |
| URI: | https://doi.org/10.1364/JOSAA.30.001146 https://dspace.iiti.ac.in/handle/123456789/9455 |
| ISSN: | 1084-7529 |
| Type of Material: | Journal Article |
| Appears in Collections: | Department of Chemistry |
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